Research Associate, Translational Medicine (In Vivo Pharmacology)

Harpoon Therapeutics in South San Francisco, CA

  • Industry: Pharmaceutical/Biotechnology - Others
  • Type: Full Time
position filled
Harpoon Therapeutics is a clinical-stage immuno-oncology company focused on the discovery and development of novel, proprietary bispecific T cell engaging biologic drug candidates for the treatment of various cancers. Harpoon’s first product, HPN424, is in clinical development for prostate cancer, and the second product HPN536 is in clinical testing for mesothelin over-expressing tumors, such as lung, pancreatic and ovarian cancers . Harpoon currently has two additional products in development and intends to introduce these into clinical development by the end of 2020. Harpoon is led by an experienced management team and has raised more than $200 million from leading life science investors. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, expertise in tumor immunology and clinical research. We are looking for a Research Associate to join our Translational Medicine group to execute preclinical studies and provide in vivo proof-of-biology data on Harpoon’s drug candidates. This position is laboratory based with the successful candidate collaborating across groups to plan, execute and analyze in vivo studies. KEY RESPONSIBILITIES ·      Independently design, execute and analyze in vitro and in vivo tumor model experiments ·      Tumor implantation which includes tissue culture of normal lymphocytes and tumor cell lines, enumeration of cell density and making serial dilutions ·      Dose mice via multiple routes of administration ·      Analyze the outcome of pharmacokinetic, pharmacodynamic and efficacy studies including statistical analyses ·      Perform relevant in vitro experiments to support the advancement of candidates to in vivo studies Maintain records, prepare reports, and make regular presentations to summarize results Adapt to and perform new responsibilities depending on the evolving needs of Harpoon Therapeutics SKILLS AND QUALIFICATIONS ·      BA/BS or MS with 2+ years’ laboratory experience in cancer biology, biochemistry, immunology or related field Direct hands on experience with  in vivo  animal studies, including animal handling, tumor and immune cell implantation, performing routine injections (sc, ip, iv), preparing test compounds, blood and tissue collection is highly desirable ·      Experience maintaining cell lines in tissue culture ·      Experience in flow cytometry is a major plus ·      Demonstrated ability to work independently with limited supervision ·      Maintain electronic laboratory notebook with high attention to detail ·      Ability to accommodate a flexible schedule which include occasional weekend responsibilities ·      Motivated, flexible, highly productive individual with strong desire to learn new techniques and to understand the scientific rationale for experimental procedures ·      Team player with excellent oral and written communication skills **PLEASE ATTACH RESUME WITH YOUR LINKEDIN PROFILE. OR, RESUMES CAN BE EMAILED TO: RESUMES@HARPOONTX.COM**

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