Scientist/Senior Scientist , Preclinical Cellular/Gene Therapy Technology Development

Genentech in San Francisco, CA

  • Industry: Pharmaceutical/Biotechnology - Others
  • Type: Full Time
position filled
The Department of Molecular Biology has an exciting opportunity for a Scientist/Senior Scientist with a strong background in viral vector engineering and application, genome editing, and/or synthetic gene circuitry. The successful applicant will lead a highly dynamic research team focused on developing and applying technologies for in vivo/ex vivo genetic manipulation and cellular reprogramming. (S)he will establish an independent research platform as well as collaborative studies across therapeutic areas. In addition, the Scientist/Senior Scientist will develop tools, in vivo models, and genetic screening methods to advance broader drug target discovery and validation efforts. The successful applicant will be expected to present their research externally and publish in peer-reviewed journals. Requirements: A self-motivated candidate with a PhD and/or MD as well as post-doctoral expertise in Genetics, Molecular Biology, Biochemistry, Cancer Biology, Immunology, Regenerative Medicine, Neurobiology, Genome Engineering, Cell/Gene Therapy, or related disciplines. Qualified applicants will have demonstrated leadership capabilities and successful, documented application of molecular genetics/genome engineering in model organisms and/or primary/stem cell systems as well as a thorough understanding of cell/tissue specific gene delivery and expression. Preferred expertise includes some or all of the following: DNA/RNA nucleases, 2D and 3D cell culture, primary and/or stem cell model generation/differentiation/application, molecular cloning, RNA/DNA/protein quantification, epigenetics, gene network manipulation/perturbation, and viral vector (AAV, lentivirus, retrovirus) engineering/production/use. Working knowledge of pooled vector-based screening, Next-Gen Sequencing (NGS), biostatistics, and/or basic bioinformatics is desirable. The successful candidate will have demonstrated a sustained record of productivity and scientific contributions beyond his/her postdoc, as evidenced by consistent high-impact publications, patents, and/or external presentations. All candidates will be expected to have excellent organizational skills, an ability to prioritize effectively, be team-oriented, collegial, and have strong interpersonal and communication skills.

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