ADME Scientist/Sr. Scientist, Small Molecule -DMPK

Genentech in South San Francisco, CA

  • Type: Full Time
position filled
The Position

We are seeking an exceptional individual for a Scientist position within the In Vitro ADME group in the Small Molecule DMPK Department at Genentech. The successful candidate will have a strong experimental background with an established track record of hands on in vitro ADME assay support and technical problem solving. A true experimentalist, the successful candidate ideally has experience supporting and influencing projects with in vitro data describing metabolic stability, protein binding and DDI potential in drug development and/or discovery. At the senior level, this person will lead a team and guide in vitro assay development and troubleshooting as well as analytical method problem solving (LC- MSMS) across the discovery development project continuum. They would work with our established team to deliver data and guidance to projects in our diverse portfolio that includes oncology, cancer immunology, neuroscience, immunology, and infectious disease targets.

Who You Are: Ph.D. in Biological Sciences/Chemistry or related field with 5-15 years of relevant ADME pharma/biotech industry experience. Must be highly motivated, organized, detail oriented with excellent communication skills, strong relevant publication track record, and excellent soft skills able to interact with a diverse group of people.

Strong understanding of drug metabolism and ADME principles including enzyme kinetics, IVIVE and DDI risk assessment.
In depth experience with in vitro ADME assays and LC-MSMS.
Experience working with project teams to guide them through ADME problem solving using in vitro data would be preferred.
Experience in writing and reviewing in vitro reports for regulatory filing is highly desired.
Experience with automation and liquid handling systems would be a plus.
Advanced cell culture techniques (co-culture, MPS etc) would also be a plus.
For the senior level position, a track record of strategic scientific leadership in the in vitro ADME field and experience managing, coaching and developing people will be required.


Who we are: Genentech's Drug Metabolism & Pharmacokinetics (DMPK) department is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates. We accomplish this through the application of state of the art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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